{"id":610275,"date":"2025-04-17T10:36:25","date_gmt":"2025-04-17T17:36:25","guid":{"rendered":"https:\/\/www.swimmingworldmagazine.com\/news\/?p=610275"},"modified":"2025-04-17T10:36:25","modified_gmt":"2025-04-17T17:36:25","slug":"swim-across-america-grants-900000-toward-first-of-its-kind-gene-editing-innovation","status":"publish","type":"post","link":"https:\/\/www.swimmingworldmagazine.com\/news\/swim-across-america-grants-900000-toward-first-of-its-kind-gene-editing-innovation\/","title":{"rendered":"Swim Across America Grants $900,000 Toward First-of-Its-Kind Gene Editing Innovation"},"content":{"rendered":"<div>Swim Across America, the nonprofit funding innovative clinical trials and patient-centered programs for cancer, is proud to announce the award of two $450,000 grants to two of its beneficiaries, Alliance for Cancer Gene Therapy (ACGT) and Dana-Farber Cancer Institute, to support the work of novel gene and base editing techniques used in advanced cancer research, including targeted therapies, immunotherapies and cellular therapies. The two-year grants will specifically support the work of scientific investigators <strong>Joseph Fraietta<\/strong>, PhD, at the University of Pennsylvania through ACGT, and <strong>Pietro Genovese<\/strong>, PhD, at Dana-Farber Cancer Institute, for their work in groundbreaking cell and gene therapy cancer research. This financial support paves the way for more effective therapies across many cancer types including solid tumors, offering potential new hope for patients with hard to treat cancer types or limited treatment options.<\/div>\n<div><\/div>\n<div>\u201cGene editing, including CRISPR, are some of the most promising frontiers in cancer research allowing for advances in targeted therapies, immunotherapies, CAR-T cell therapy and early\/minimal residual disease detection, diagnostics and cancer vaccines,\u201d said Rob Butcher, CEO of Swim Across America. &#8220;These grants to Dr. Fraietta through ACGT, and Dr. Genovese at Dana-Farber, will help accelerate the advancement of potential gene-edited cancer treatments that could transform how we treat patients and their quality of life. Just as our previous funding has helped develop immunotherapy treatments that are saving lives today, we believe these pointed investments will help accelerate the next generation of cancer breakthroughs.\u201d<\/div>\n<div><\/div>\n<div><strong>Joseph Fraietta<\/strong>, PhD, through Swim Across America\u2013Fairfield County beneficiary Alliance for Cancer Gene Therapy, is developing an innovative &#8220;off-the-shelf&#8221; cell therapy for aggressive cancers. His research uses a precise gene-editing tool called a &#8220;base editor&#8221; to create more effective CAR T cells that can target cancers with KRAS mutations, found in 20-25% of all cancers including lung, colon and pancreatic cancer. His team is also developing &#8220;micropharmacies&#8221; &#8211; immune cells engineered to release powerful cancer-fighting signals directly at tumor sites while minimizing side effects.<\/div>\n<div><\/div>\n<div><strong>Pietro Genovese<\/strong>, PhD, at Dana-Farber, is taking a revolutionary approach to treating acute myeloid leukemia (AML). Rather than targeting cancer cells directly, his team is creating &#8220;stealth&#8221; healthy blood cells engineered to survive cancer treatments while allowing the selective elimination of cancer cells. This innovative strategy could provide less toxic treatment options for AML and other blood cancers where traditional therapies often harm healthy cells along with cancerous ones.<\/div>\n<div>\u201cWith the current funding landscape and resources potentially constrained, nonprofit organizations play a vital role in ensuring innovative cancer research moves forward,&#8221; said Evan Vosburgh, MD, Research and Grants committee chair for Swim Across America. &#8220;These targeted grants support precisely the kind of high-risk, high-reward research that could revolutionize cancer treatment, but might otherwise go unfunded. By supporting early-stage research in cell and gene therapy, we&#8217;re helping bridge critical funding gaps and accelerating the development of potentially life-saving treatments.\u201d<\/div>\n<div><\/div>\n<div>Swim Across America has raised more than $100 million for cancer research since its founding in 1987 and has a strong track record of funding transformative research, including clinical trials that led to FDA-approved immunotherapy medicines Keytruda, Opdivo, Yervoy and Tecentriq. The organization was also a grant funder of Memorial Sloan Kettering&#8217;s landmark clinical trial that achieved a 100% success rate treating advanced rectal cancer patients with dostarlimab.<\/div>\n<div><\/div>\n<div><strong>About Swim Across America\u00a0<\/strong><\/div>\n<div><\/div>\n<div>Swim Across America hosts open water and pool swims in numerous communities nationwide, from Nantucket to under San Francisco&#8217;s Golden Gate Bridge. More than 150 Olympians support the organization, including Michael Phelps, Kate Douglass, Missy Franklin and Ryan Lochte. The organization supports more than 60 cancer research projects annually and has ten named Swim Across America Labs at major institutions nationwide. To learn more visit <a href=\"https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2CuJGNUppvuUTYuJF-eUU8AAF_lKgNXzHPQdIkJ_AMq0yqqNElgFC1b3W55cQArGDNcLIw7LkATK22Chn6WyrJ4zcBkoM1vU0UJISb8SzpcA_6dOEDQoSkRkUPOqgymqoaF56nIQRh4ppqN5bXZ0Eg8drWku3FOcQVxKbT75qq6wh5XXivOIk-DOdFrlFWyEdtTnwQMrwZeSUJsc\" target=\"_blank\" rel=\"nofollow noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2CuJGNUppvuUTYuJF-eUU8AAF_lKgNXzHPQdIkJ_AMq0yqqNElgFC1b3W55cQArGDNcLIw7LkATK22Chn6WyrJ4zcBkoM1vU0UJISb8SzpcA_6dOEDQoSkRkUPOqgymqoaF56nIQRh4ppqN5bXZ0Eg8drWku3FOcQVxKbT75qq6wh5XXivOIk-DOdFrlFWyEdtTnwQMrwZeSUJsc&amp;source=gmail&amp;ust=1744994867624000&amp;usg=AOvVaw3jtNI-B5rswQzyxiMb_L34\">swimacrossamerica.org<\/a> or follow on social media<a href=\"https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2Jvzjk9gOj1qVfpNBIQy3pfoGC9n0Nc4qt4bcaccg5GI3qqNElgErqi8KBiqh506EeIHfaypGaRY0B-OVO0WFxTF963iebxE-TWgARg9HCef8oHzu6FTwh7_mvbtKt0k40wPD2X0gU4tFRxkuz0dxsBla65RVCqX3ABuIOFEE5stwgKyGr4v3QxTBS6_z2F9feR0D6-fNYwZEWaMe7vhS_PI\" target=\"_blank\" rel=\"nofollow noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2Jvzjk9gOj1qVfpNBIQy3pfoGC9n0Nc4qt4bcaccg5GI3qqNElgErqi8KBiqh506EeIHfaypGaRY0B-OVO0WFxTF963iebxE-TWgARg9HCef8oHzu6FTwh7_mvbtKt0k40wPD2X0gU4tFRxkuz0dxsBla65RVCqX3ABuIOFEE5stwgKyGr4v3QxTBS6_z2F9feR0D6-fNYwZEWaMe7vhS_PI&amp;source=gmail&amp;ust=1744994867624000&amp;usg=AOvVaw1gk_cHIvGuHGTJbFzKmlWj\"> @SwimAcrossAmerica<\/a> on Facebook and<a href=\"https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2nhE_MTFbbzbP_7H9t7HAX_Z5luTNXeQluAyksYR6VZI6qqNElgFpgt17skYnIU3AcCQ6EjIOnk4admXNNdVU3uwCv23qoPtjQE7Bp2uwdMLd9ylLxO43mB-ReChe1mYw1qQCIkivcg4WJyIGDOhOLwfLtHUSkxaTwbw2dW3K4ShQ1F5apo67_bgWYsRZJIkUyf1q2EU2\" target=\"_blank\" rel=\"nofollow noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/swimacrossamerica-dot-yamm-track.appspot.com\/2nhE_MTFbbzbP_7H9t7HAX_Z5luTNXeQluAyksYR6VZI6qqNElgFpgt17skYnIU3AcCQ6EjIOnk4admXNNdVU3uwCv23qoPtjQE7Bp2uwdMLd9ylLxO43mB-ReChe1mYw1qQCIkivcg4WJyIGDOhOLwfLtHUSkxaTwbw2dW3K4ShQ1F5apo67_bgWYsRZJIkUyf1q2EU2&amp;source=gmail&amp;ust=1744994867624000&amp;usg=AOvVaw1L5kur4PiED5VJb7r8aCVU\"> @SAASwim<\/a> on Instagram.<\/div>\n<div><\/div>\n<div><span class=\"TextRun SCXW212265482 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW212265482 BCX8\">\u2014 The above press release was posted by Swimming World in conjunction with SAA<\/span><\/span><span class=\"TextRun SCXW212265482 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW212265482 BCX8\">. For press releases and advertising inquiries please contact<\/span><\/span> <a class=\"Hyperlink SCXW212265482 BCX8\" href=\"mailto:Advertising@SwimmingWorld.com\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Underlined SCXW212265482 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW212265482 BCX8\" data-ccp-charstyle=\"Hyperlink\">Advertising@SwimmingWorld.com<\/span><\/span><\/a><span class=\"TextRun SCXW212265482 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW212265482 BCX8\">.<\/span><\/span><span class=\"EOP SCXW212265482 BCX8\" data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Swim Across America, the nonprofit funding innovative clinical trials and patient-centered programs for cancer, is proud to announce the award of two $450,000 grants to two of its beneficiaries, Alliance<\/p>\n","protected":false},"author":3915,"featured_media":596446,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"dois","enabled":false},"version":2}},"categories":[122077],"tags":[50988],"class_list":["post-610275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-americas","tag-swim-across-america"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v24.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Swim Across America Grants $900,000 Toward Gene Innovation<\/title>\r\n<meta name=\"description\" content=\"Swim Across America Grants $900,000 Toward First-of-Its-Kind Gene Editing Innovation. 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